Martin Overseas

• Treatment of Parasitic infections

Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), have been developed and distributed, major challenges remain regarding vaccine production and allocation.1 The identification of inexpensive, widely available, and effective therapies against Covid-19 is of great importance. The repurposing of existing medicines that are widely available and that have reasonably well understood safety profiles has appeal.2

One drug that has received considerable public use and interest is ivermectin, which is typically used as an antiparasitic drug. Ivermectin inhibits the chloride channels of helminthic parasites and has been shown to have clinical efficacy for the treatment of onchocerciasis, strongyloidiasis, and ectoparasitic infection (e.g., scabies).3 The in vitro antiviral activity of ivermectin has been explored against a spectrum of viruses, including severe acute respiratory syndrome coronavirus 1, human immunodeficiency virus, dengue virus, Zika virus, yellow fever virus, West Nile virus, Hendra virus, chikungunya virus, Semliki Forest virus, Sindbis virus, and avian influenza virus.4

More than 60 randomized trials of ivermectin for the treatment of Covid-19 have been registered, and findings have been reported for as many as 31 clinical trials.5 The results have been discordant, and various review groups interpret the evidence differently — some advocating for benefits of ivermectin, and others reticent to conclude a benefit.6-8 However, most trials have been small, and several have been withdrawn from publication owing to concerns about credibility.9

To evaluate the efficacy of ivermectin for the prevention of progression of Covid-19 resulting in hospitalization among outpatients with SARS-CoV-2 infection, we conducted a randomized, placebo-controlled, adaptive platform trial (TOGETHER) in the state of Minas Gerais, Brazil. Although various interventions were assessed in this trial, we report here on the use of ivermectin at a dose of 400 μg per kilogram of body weight for 3 days as compared with placebo.

Iverset 12mg Tablets contain Ivermectin, an antiparasitic medication used to treat a variety of parasitic infections. It works by paralyzing and killing the parasites.

Molnuvid 200mg Molnupiravir Capsules are an antiviral medication primarily used to treat mild to moderate COVID-19 in individuals at high risk of developing severe disease. Molnupiravir works by inhibiting the replication of the SARS-CoV-2 virus (the virus that causes COVID-19) and preventing its spread within the body.

Iversun 12mg Tablet contains Ivermectin, an antiparasitic medication used to treat a variety of parasitic infections. It is commonly prescribed for conditions like:

• Strongyloidiasis (a parasitic infection caused by roundworms)

• Onchocerciasis (river blindness)

• Scabies (a skin infestation caused by mites)

• Head lice

Ivermectin works by paralyzing and killing the parasites. The 12mg dosage is typically used for more severe or specific cases, depending on the condition being treated. Always follow the prescribed dosage and instructions from a healthcare provider.

Remdesivir, sold under the brand name Veklury,^[13][14] is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences.^[15] It is administered via injection into a vein.^[16][17] During the COVID‑19 pandemic, remdesivir was approved or authorized for emergency use to treat COVID‑19 in numerous countries.^[18]

Remdesivir was originally developed to treat hepatitis C,^[19] and was subsequently investigated for Ebola virus disease and Marburg virus infections^[20] before being studied as a post-infection treatment for COVID‑19.^[21]

Remdesivir is a prodrug that is intended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase.^[22]

The most common side effect in healthy volunteers is raised blood levels of liver enzymes.^[13] The most common side effect in people with COVID‑19 is nausea.^[13] Side effects may include liver inflammation and an infusion-related reaction with nausea, low blood pressure, and sweating.^[23]

The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.^[24

Fabiflu 400mg Tablet is an antiviral medication primarily used for the treatment of mild to moderate COVID-19 in adults. It contains Favipiravir as the active ingredient and works by inhibiting the replication of the SARS-CoV-2 virus, which causes COVID-19.

Movfor 200mg Molnupiravir Tablet is an antiviral medication primarily used to treat COVID-19 in individuals who are at high risk of developing severe disease. It works by inhibiting the replication of the virus in the body.